Estimation of the state of the microbiome in the elderly with impairments of carbohydrate and lipid exchange by the method of microbiome-associated exposomics

We performed the biochemical analysis and studied chemical composition of blood samples in 163 people 45-90 years old with type 2 diabetes mellitus dyslipidemia. examined concentrations following compounds samples: fatty acids, aldehydes, styrenes microbial origin, as well levels glucose, triglycerides, cholesterol, lipids low high density. The was determined by gas chromatography-mass spectrometry. aldehydes (including octadecenaldehyde (18a)), were used to calculate total molar concentration small molecules originating from microbes (SMOM), hydroxy acids - derivatives hydroxyl residue Lipid A, bacterial endotoxin (3OH-FA), grouped which determine representation main four phylotypes human microbiome: Actinobacteria , Bacteroidetes Proteobacteria Firmicutes . Over course this study, we obtained data that show increase compounds, 3OH-FA patients carbohydrate metabolism disorders due 2. observed a decrease lipid disorders, an including combined disorders. There direct correlation between level triglycerides inverse glucose these control group. did not reveal statistically significant changes markers nor correlations parameters microbiome